AMPRENAVIR
161814-49-9 Basic informationMore
- Product Name:AMPRENAVIR
- Synonyms: KVX-478 AGENERASE AMPRENAVIR 141W94 PROZEI 141W94, KVX-478, Agenerase, Prozei, Carbamic acid, (1S,2R)-3-(4-aminophenyl)sulfonyl(2-methylpropyl)amino-2-hydroxy-1-(phenylmethyl)propyl-, (3S)-tetrahydro-3-furanyl ester Angenerase
- CAS:161814-49-9
- MF:C25H35N3O6S
- MW:505.63
- EINECS:827-179-5
- Mol File:161814-49-9.mol
-
USE
Amprenavir was launched as Agenerase in the US for the treatment of
AIDS patients in combination with approved agent antiretroviral nucleoside
analogs. It is the fifth non-peptidic inhibitor of HIV-1 protease to be marketed in
this indication after the last approved Neflinavir. Amprenavir, designed via a
structure-based process, is the smallest molecule in the 《navir》 class and
exhibits a reduced peptidic character. An improved process for preparation
comprising four steps from a (1S, 2R)-2-hydroxy-3-aminopropylcarbamate has
been developed. Amprenavir is a potent inhibitor of HIV-1 aspartyl protease (Ki
= 0.6nM), an enzyme required by the virus to cleave pro-form polyproteins to
structural proteins during the last stage in the replication process. The
compound displays good oral bioavailability in humans and penetrates the CNS,
which is an important advantage in long-term treatment. Its plasma half-life is
approximately 10h. Treatment with Amprenavir in combination with nucleoside
analog reverse transcriptase inhibitors considerably decreases viral load and
restores CD4+ T-cell counts in patients with HIV infection.
Lastest Price from AMPRENAVIR manufacturers
- AMPRENAVIR
-
- US $10.00-200.00/G
- CAS:161814-49-9
- Min. Order: 100G
- Purity: 99.99%
- Supply Ability: 20MT
- 2022-11-05
- Amprenavir
-
- US $0.00 /KG
- CAS:161814-49-9
- Min. Order: 1KG
- Purity: 98.1%
- Supply Ability: 100 tons
- 2022-02-09
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- Company Name:Shaoxing Shunbang Medical Technology Co. LTD
- Tel: 13355710117
- Products Intro:Product Name:AMPRENAVIR
CAS:161814-49-9
Purity:99% ;250mg/1978 Package:250mg;1g - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Amprenavir, 98%
CAS:161814-49-9
Purity:98% Package:50mg;5mg More... - CB Index:76
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:AMPRENAVIR
CAS:161814-49-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:AMprenavir
CAS:161814-49-9
Remarks:C13291 More... - CB Index:61
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- Company Name:Shanghai Scientia Pharmaceutical Technology Co., Ltd.
- Tel:21-21-54301573 13917723525
- Products Intro:Product Name:AMPRENAVIR
CAS:161814-49-9
Purity:99%min Package:50g;100g;250g;500g;1kg;5kg;10kg;25kg;50kg More... - CB Index:62
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