Peramivir

• Product Name:Peramivir
• Synonyms: (1S,2S,3R,4R)-3-((S)-1-AcetaMido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid (1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid (1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic acid Aids114230 Aids-114230 Bcx-1812 Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-, (1S,2S,3R,4R)- Rwj-270201
• CAS:330600-85-6
• MF:C15H28N4O4
• MW:328.41
• EINECS:
• Mol File:330600-85-6.mol
• 

Peramivir is a neuraminidase (NA) inhibitor that was approved in Japan in 2010 for treatment of patients with influenza. It is the only NA inhibitor available for IV use and is the first of two NA inhibitors approved in 2010, the second being the inhaled drug laninamivir octanoate . Peramivir is the only NA inhibitor approved for IV use,which gives it a unique place in influenza treatment for seriously ill patients. Peramivir was discovered using structure-based drug design and is synthesized in six steps from Boc-protected methyl (1S,4R)-4-amino-cyclopent-2-enecarboxylate, which is prepared from 2-azabicyclo[2.2.1]hept-5-en-3-one. Cycloaddition of the cyclopentene olefin with a nitrile oxide provided an intermediate fused cyclopentane-dihydroisoxazole. Hydrogenolysis and acetylation set up a fully functionalized cyclopentane with all four stereocenters established. Deprotection of the amine and acid groups was followed by installation of the guanidine moiety to provide peramivir. Like zanamivir and oseltamivir, peramivir is a potent inhibitor of influenza virus A and B NA [strain A(H1N1) IC₅₀= 0.34 nM; strain A(H3N2) IC₅₀= 0.60 nM; strain B IC₅₀= 1.36 nM]. However, peramivir is less potent against oseltamivirresistant viruses that have the H275Y NA mutation. These viruses remain sensitive to zanamivir. Peramivir is active against influenza A and B viruses and has a lowenzymatic off-rate, suggesting that it could inhibitNAactivity for a prolonged period and allow lower frequency of dosing. Peramivir has proven efficacious in preclinical animal models of influenza infection.<p><span style="font-family:arial,helvetica,sans-serif; font-size:14px">Peramivir is a</span>&nbsp;new antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza</p> <p><span style="font-family:arial,helvetica,sans-serif; font-size:14px">Peramivir is&nbsp;</span>a&nbsp;member of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.</p>

• peramivir
• 
• US $0.00 /kg
• CAS:330600-85-6
• Min. Order: 25kg
• Purity: 98%
• Supply Ability: Inquiry
• 2024-03-28

• Peramivir
• 
• US $200.00 /kg
• CAS:330600-85-6
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 1000kg/Month
• 2023-06-26

• Company Name:Hangzhou FST Pharmaceutical Co., Ltd
• Tel:0571-88938521 18667135863
• Products Intro:Product Name:Peramivir
  CAS:330600-85-6
  Package:25kg
• CB Index:60
• Related Information:Catalog(115)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:PeraMivir
  CAS:330600-85-6
  Package:10Mg,1Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:PeraMivir(RWJ-270201,BCX-1812)
  CAS:330600-85-6
  Remarks:C13998 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Wuhan Fortuna Chemical Co., Ltd
• Tel:027-59207852 13308628970
• Products Intro:Product Name:Peramivir
  CAS:330600-85-6
  Purity:99% Package:100g，500g，1kg More...
• CB Index:58
• Related Information:Catalog(2866)

• Company Name:Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
• Tel:022-60116533 13207668525
• Products Intro:Product Name:Peramivir
  CAS:330600-85-6
  Purity:99.00% Package:100g,500g,1kg,25kg More...
• CB Index:58
• Related Information:Catalog(683)