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Zolmitriptan

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139264-17-8 Basic informationMore
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Zolmitriptan, the second triptan marketed (approved in1997), has a much better bioavailability (40%–48%) thansumatriptan. It is rapidly absorbed after oral or nasal sprayadministration. It also has an orally disintegrating tablet formulation(Zomig ZMT), which can be taken without water.Zolmitriptan undergoes rapid N-demethylation via CYP1A2to a more potent, active metabolite, N-desmethylzolmitriptan,which is 2 to 6 times more potent than the parentdrug. This active metabolite was detected 5 minutesafter dosing and accounts for about two thirds of the plasmaconcentration of the administered dose of the parent drug.284Thus, it is reasonable to assume that the therapeutic effectsand especially the CNS side effects of zolmitriptan must bein part attributed to the plasma levels of this active metabolite,at least until it is further degraded by hepatic MAO-Ato its inactive indole acetic acid derivatives.
Lastest Price from Zolmitriptan manufacturers
  • Zolmitriptan
  • US $1.00 /g
  • CAS:139264-17-8
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 100kg
  • 2024-04-19
  • Zolmitriptan
  • US $100.00-60.00/Kg/Bag
  • CAS:139264-17-8
  • Min. Order: 1Kg/Bag
  • Purity: 0.99
  • Supply Ability: 20 tons
  • 2024-04-10

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