AZD-2858

• Product Name:AZD-2858
• Synonyms: AZD 2858 AZD2858 AZD-2858 3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-pyrazinecarboxamide 2-Pyrazinecarboxamide, 3-amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl- 3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-pyrazinecarboxamide AZD2858 3-Amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide 3-Amino-6-{4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl}-N-(3-pyridinyl)-2-pyrazinecarboxamide
• CAS:486424-20-8
• MF:C21H23N7O3S
• MW:453.52
• EINECS:
• Mol File:486424-20-8.mol
• 

In rats, oral AZD2858 treatment causes a dose-dependent increase in trabecular bone mass compared to control after a two-week treatment with a maximum effect at a dose of 20 mg/kg once daily (total BMC: 172% of control). A small but significant effect is also seen at cortical sites (total BMC: 111% of control). AZD285 treatment (30 μmol/kg) on rats daily for up to 3 weeks shows an increase in both mineral density (of 28% at 2 weeks and 38% at 3 weeks) and mineral content (of 81% at 2 weeks and 93% at 3 weeks) in the calluses. AZD285 treatment makes the fractures heals more rapidly, with a bony callus without an obvious endochondral component. AZD2858 produces time-dependent changes in serum bone turnover biomarkers and increases bone mass over 28 days exposure in rats. After 7 days, AZD2858 increases the bone formation biomarker P1NP, and reduces the resorption biomarker TRAcP-5b, indicating increased bone anabolism and reduced resorption in rats.

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:AZD-2858
  CAS:486424-20-8
  Purity:>98% Package:100MG Remarks:4870 More...
• CB Index:58
• Related Information:Catalog(4727)

• Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
• Tel:400-400-6206333 18521732826
• Products Intro:Product Name:AZD2858
  CAS:486424-20-8
  Purity:10mM in DMSO Package:1ml/RMB 720.90 More...
• CB Index:65
• Related Information:Catalog(25003)

• Company Name:Suzhou yacoo science co.,Ltd
• Tel:0512-87182056 18013166090
• Products Intro:Product Name:AZD2858
  CAS:486424-20-8
  Purity:98% Package:10g;50g;1kg;5Kg;25kg;
• CB Index:60
• Related Information:Catalog(7295)