Radotinib
926037-48-1 Basic informationMore
- Product Name:Radotinib
- Synonyms: IY5511 Radotinib Radotinib(IY-5511) 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-(pyrazin-2-yl)pyrimidin-2-ylamino)benzamide 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phe... Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(2-pyrazinyl)-2-pyrimidinyl]amino]- RADOTINIB; IY5511 HCL. IY5511 HCl.
- CAS:926037-48-1
- MF:C27H21F3N8O
- MW:530.5
- EINECS:
- Mol File:926037-48-1.mol
-
USE
Radotinib, an inhibitor of Bcr–Abl tyrosine kinase,was approved in January 2012 in Korea as a second-line treatment for chronic myeloid leukemia (CML).
Radotinib is a TKI with a similar structure to the second-generation TKI, nilotinib, in which a pyridyl group has been replaced with a pyrazinemoiety. The in vitro activity of radotinib against a variety of tumor cell lines is disclosed in an issued patent. Radotinib was significantly more potent than imatinib in all of the cell lines tested. The synthesis of radotinib via amide coupling is described in the patent literature.
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- Company Name:Jia Xing Isenchem Co.,Ltd
- Tel:0573-85285100 18627885956
- Products Intro:CAS:926037-48-1
Purity:98% (HPLC or GC) Package:25g,100g,500g;1kg More... - CB Index:66
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:Radotinib(IY-5511)
CAS:926037-48-1
Purity:>98%,BR Package:5MG;25MG;100MG Remarks:MB4589 - CB Index:58
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- Company Name:Taizhou Tongxin Bio-Tech Co., Ltd
- Tel:0523-18601685-898 18652728585
- Products Intro:Product Name:Radotinib
CAS:926037-48-1
Purity:98% More... - CB Index:60
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- Company Name:Hangzhou J&H Chemical Co., Ltd.
- Tel:0571-+86-571-87396432
- Products Intro:Product Name:4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide
CAS:926037-48-1
Purity:99% Package:1g;1kg,100kg,1000kg - CB Index:59
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- Company Name:Cool Pharm, Ltd
- Tel:021-60455363 18019463053
- Products Intro:Product Name:Radotinib
CAS:926037-48-1
Purity:98.0% Package:10g;25g;100g;500g;1kg;5kg;10kg More... - CB Index:58
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