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Amantadine

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USE
Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.
Lastest Price from Amantadine manufacturers
  • Amantadine
  • US $50.00-45.00/kg
  • CAS:768-94-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 8000kg
  • 2024-04-24
  • Amantadine
  • US $32.00-1.40/kg
  • CAS:768-94-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: g-kg-tons, free sample is available
  • 2024-04-07

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  • Company Name:Sichuan Zhongbang Pharma CO.,LTD
  • Tel:0830-0830-2585019 13679670161
  • Products Intro:Product Name:1-AdaMantanaMine
    CAS:768-94-5
    Purity:98.5% Remarks:A004 More...
  • CB Index:69
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  • Tel:0572-16762203950 16762203950
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
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