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Amantadine

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USE
Amantadine has been used for years as a treatment for Parkinson disease. The adamantanamines have twomechanisms in common:they inhibit an early step in viralreplication, most likely viral uncoating,and in somestrains, they affect a later step that probably involves viral assembly,possibly by interfering with hemagglutinin processing.The main biochemical locus of action is the influenzatype A virus M2 protein, which is an integral membrane proteinthat functions as an ion channel. The M2 channel is a protontransport system. By interfering with the function of theM2 protein, the adamantanamines inhibit acid-mediated dissociationof the ribonucleoprotein complex early in replication.They also interfere with transmembrane proton pumping,maintaining a high intracellular proton concentrationrelative to the extracellular concentration and enhancingacidic pH-induced conformational changes in the hemagglutininduring its intracellular transport at a later stage. The conformationalchanges in hemagglutinin prevent transfer of thenascent virus particles to the cell membrane for exocytosis.
Lastest Price from Amantadine manufacturers
  • Amantadine
  • US $980.00-750.00/kg
  • CAS:768-94-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 5000
  • 2024-12-20
  • Amantadine
  • US $0.00 /Kg/Drum
  • CAS:768-94-5
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 1000kg
  • 2024-12-13

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  • Company Name:Sichuan Zhongbang Pharma CO.,LTD
  • Tel:0830-0830-2585019 13679670161
  • Products Intro:Product Name:1-AdaMantanaMine
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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