XL518
934660-93-2 Basic informationMore
- Product Name:XL518
- Synonyms: XL518 RG7420 [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]Methanone GDC-0973(XL-518) (S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)Methanone XL518 ,GDC-0973 GDC-0973/RG7420 Methanone, [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]-
- CAS:934660-93-2
- MF:C21H21F3IN3O2
- MW:531.31
- EINECS:
- Mol File:934660-93-2.mol
-
USE
A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.
Lastest Price from XL518 manufacturers
- Cobimetinib
-
- US $15.00-10.00/KG
- CAS:934660-93-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
- Cobimetinib
-
- US $15.00-10.00/KG
- CAS:934660-93-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-10
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Cobimetinib (GDC-0973; XL518)
CAS:934660-93-2
Purity:98% Package:1g Remarks:C13708 More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:Shanghai VastPro Technology Development Co., Ltd.
- Tel:021-20608178 18930468532
- Products Intro:Product Name:Cobimetinib
CAS:934660-93-2
Purity:手性100% Package:1g/RMB 3000;1Kg - CB Index:58
- Related Information:Catalog(15)
- Company Name:Beijing HwrkChemical Technology Co., Ltd
- Tel:010-89508211 18501085097
- Products Intro:Product Name:XL518
CAS:934660-93-2
Purity:98.00% Package:1g - CB Index:55
- Related Information:Catalog(8418)
- Company Name:Jia Xing Isenchem Co.,Ltd
- Tel:0573-85285100 18627885956
- Products Intro:CAS:934660-93-2
Purity:98% (HPLC or GC) Package:25g,100g,500g;163kg More... - CB Index:66
- Related Information:Catalog(9413)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:XL518
CAS:934660-93-2
Purity:>98%,BR Package:5mg;25mg Remarks:MB3615 More... - CB Index:58
- Related Information:Catalog(4727)
- Company Name:Shanghai Topbiochem Technology Co., Ltd
- Tel:021-58170097
- Products Intro:Product Name:XL518
CAS:934660-93-2
Purity:98% Package:25g;100g;500g;1kg More... - CB Index:58
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