StaupriMide

• Product Name:StaupriMide
• Synonyms: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide N-Benzoyl-7-oxostaurosporine benzaMide deriv. Stauprimide Stauprimide - CAS 154589-96-5 - Calbiochem Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- Stauprimide-d5 N-((5S,6R,7R,9S)-6-Methoxy-5-methyl-14,16-dioxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide
• CAS:154589-96-5
• MF:C35H28N4O5
• MW:584.62
• EINECS:
• Mol File:154589-96-5.mol
• 

Stauprimide is an enhancer stem cell differentiation into endoderm. In vitro differentiation of embryonic stem cells is of great interest to regenerative medicine, and current protocols are labor-intensive and expensive. Small molecules that induce or enhance differentiation are highly desired. High-content screening identified compounds that enhance endodermal differentiation in the presence of low levels of Activin A. Stauprimide increased definitive endodermal markers but not markers for visceral/parietal endoderm or mesoderm. Stauprimide-differentiated cells could be further differentiated into hepatocytes. Stauprimide treatment during differentiation decreased the concentration of Activin A required for definitive endoderm formation, and it eliminated the need for serum. The mechanism of action of stauprimide is to sensitize cells for differentiation. Stauprimide enabled differentiation into other cell lineages under varying differentiation conditions, including neurons, hematopoietic mesoderm, beating cardiac myocytes, and skeletal muscle. Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumour agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells. Labelled Stauprimide (S684700). It is an enhancer stem cell differentiation into endoderm. Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumor agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:StaupriMide
  CAS:154589-96-5
  Package:50Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:StaupriMide;[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-Methoxy-9-Methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-MethylbenzaMide
  CAS:154589-96-5
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15848)

• Company Name:Shandong Xiya Chemical Co., Ltd
• Tel:4009903999 13355009207
• Products Intro:CAS:154589-96-5
  Purity:>=99.0% Package:1mg;5mg
• CB Index:57
• Related Information:Catalog(18739)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:Stauprimide
  CAS:154589-96-5
  Purity:>98%,BR Package:1MG Remarks:MB0265
• CB Index:58
• Related Information:Catalog(4665)

• Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
• Tel:400-400-6206333 18521732826
• Products Intro:Product Name:Stauprimide
  CAS:154589-96-5
  Purity:99% Package:5mg/RMB 4669.90;1mg/RMB 1556.90 More...
• CB Index:65
• Related Information:Catalog(25014)