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Etodolac

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41340-25-4 Basic informationMore
USE
Etodolac (Lodine, Ultradol), a chiral, COX-2 selectiveNSAID drug that is marketed as a racemate, possesses an indolering as the aryl portion of this group of NSAID drugs.It shares many similar properties of this group and is indicatedfor short- and long-term management of pain and OA.<br/>Similar to ketorolac, etodolac exhibits several uniqueenantioselective pharmacokinetic properties. For example,the “inactive” (R)-enantiomer has approximately a 10-foldhigher plasma concentration than the active (S)-enantiomer.Furthermore, the active (S)-enantiomer is less protein boundthan its (R)-enantiomer and therefore has a very large volumeof distribution. It is well absorbed with an elimination halflifeof 6 to 8 hours. Etodolac is extensively metabolized intothree major inactive metabolites, 6-hydroxy etodolac (via aromatichydroxylation), 7-hydroxy-etodolac (via aromatic hydroxylation),and 8-(1'-hydroxylethyl) etodolac (via benzylichydroxylation), which are eliminated as the correspondingether glucuronides. Its unstable, acyl glucuronide, however,is subject to enterohepatic circulation and reactivation tothe parent drug, similar to other NSAIDS in this class.
Lastest Price from Etodolac manufacturers
  • Etodolac
  • US $1.00-1.00/KG
  • CAS:41340-25-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • 2024-02-01
  • Etodolac
  • US $1.00-1.00/KG
  • CAS:41340-25-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • 2024-02-01

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  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:010-82848833 400-666-7788
  • Products Intro:Product Name:Etodolac, 98%, a COX inhibitor
    CAS:41340-25-4
    Purity:98% Package:25G;5G More...
  • CB Index:76
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    Purity:>98.0%(LC)(T) Package:5g;25g Remarks:E0858 More...
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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  • Products Intro:Product Name:Etodolac;(RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)aceticacid
    CAS:41340-25-4
    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
  • CB Index:69
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  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456
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    CAS:41340-25-4
    Remarks:C13649 More...
  • CB Index:61
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  • Company Name:TCI (Shanghai) Development Co., Ltd.
  • Tel:021-67121386
  • Products Intro:Product Name:Etodolac
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    Purity:98.0% LC&T Package:25G,5G More...
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  • Company Name:BeiJing Hwrk Chemicals Limted
  • Tel:0757-86329057 18501085097
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    CAS:41340-25-4
    Purity:98.00% Package:5g
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  • Company Name:Energy Chemical
  • Tel:021-021-58432009 400-005-6266
  • Products Intro:Product Name:Etodolac
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