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Cetilistat

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282526-98-1 Basic informationMore
USE
Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m<sup>2</sup> in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. The synthesis of cetilistat involves condensation of a hexadecylcarbonochloridate with 2-amino-5-methylbenzoic acid; other analogs were synthesized by varying the carbonochloridate and 2-aminobenzoic acid components. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC<sub>50s</sub> of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin.
Lastest Price from Cetilistat manufacturers
  • Cetilistat
  • US $10.00 /kg
  • CAS:282526-98-1
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 20ton
  • 2024-12-18
  • Cetilistat
  • US $0.00 /Kg/Drum
  • CAS:282526-98-1
  • Min. Order: 1KG
  • Purity: 99%min HPLC
  • Supply Ability: 1000KGS
  • 2024-12-13

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  • Company Name:Shandong Haiwo Biological Technology Co., Ltd.
  • Tel:0531-87586188 13046003282
  • Products Intro:Product Name:Cetilistat
    CAS:282526-98-1
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  • Company Name:Shandong Fuchuang Pharmaceutical Technology Co. , Ltd.
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    Purity:99% Package:1kg;25kg;100kg
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  • Company Name:Jinan Hongwan Biotechnology Co., Ltd.
  • Tel:0531-58767175 13220585822
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  • Company Name:Chengdu Pengshengyue Pharmaceutical Technology Co. , Ltd.
  • Tel:171-5642-2032 19587414261
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    Purity:99 Package:1kg/RMB 2200;25kg/RMB 1900
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  • Company Name:Xi'an Lyna Bio-Tech Co., Ltd.
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    Purity:99% Package:1KG/袋/RMB 2200
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  • Company Name:Linyi Pingsheng Biotechnology Co., Ltd.
  • Tel:0375-15696900 15696900147
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    Purity:99 Package:1kg/RMB 2500;25kg/RMB 2300 Remarks:1
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