Methotrexate

• Product Name:Methotrexate
• Synonyms: METHOTREXATEFORINJECTION METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID) 4-Amino-N10-methylfolic acid Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI) L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI) L-Methotrexate Methotrexat-Ebewe METHOTREXATEC
• CAS:59-05-2
• MF:C20H22N8O5
• MW:454.45
• EINECS:200-413-8
• Mol File:59-05-2.mol
• 

The drug is available in 50-, 100-, 200-, and 1,000-mg vialsfor IV use. Methotrexate is used to treat several cancer typesincluding breast cancer, bladder cancer, colorectal cancer,and head and neck cancer. The mechanism of action ofmethotrexate involves inhibition of DHFR leading to a depletionof critical reduced folates. The reduced folates arenecessary for biosynthesis of several purines and pyrimidines.Resistance to methotrexate can occur because ofdecreased carrier-mediated transport of drug into cells orincreased expression of the target enzyme DHFR. Oralbioavailability varies with dose because of saturable uptakeprocesses, and high doses are required to reach therapeuticlevels in the CNS. The majority of drug dosage is excretedunchanged in the urine. The renal excretion of methotrexateis inhibited by several carboxylic acid drugs such as penicillins,probenecid, nonsteroidal anti-inflammatory agents,and aspirin. Methotrexate enhances 5-FU antitumor effectswhen given 24 hours prior to the fluoropyrimidine.Methotrexate toxicity includes myelosuppression, mucositis,nausea, vomiting, severe headaches, renal toxicity, acutecerebral dysfunction, skin rash, and hyperpigmentation.

• Methotrexate
• 
• US $150.00 /kg
• CAS:59-05-2
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 500kg
• 2024-12-18

• Methotrexate
• 
• US $15.00-10.00/kg
• CAS:59-05-2
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 2000kg
• 2024-12-17

• Company Name:Suzhou Surui Pharmaceutical Chemical Co., Ltd
• Tel:0512-68086196 15051406830
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:99%，EP9，USP43 Package:1kg;5kg;25kg
• CB Index:58
• Related Information:Catalog(12)

• Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
• Tel:020-39119399 18927568969
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:98% Package:1G; 5G; 25G; 100G; 1KG; 5KG More...
• CB Index:55
• Related Information:Catalog(4674)

• Company Name:Zhenjiang Hongyu Biotechnology Co., Ltd
• Tel: 15189105787
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:≥99% Package:15kg/桶
• CB Index:58
• Related Information:Catalog(29)

• Company Name:Panjin Jiahe Shengshi Pharmaceutical Technology Co., Ltd
• Tel:18504053675 13032431717
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:98%-102% Package:10kg/RMB 4500
• CB Index:58
• Related Information:Catalog(45)

• Company Name:FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd
• Tel:25-8690-7345 18651693585
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:99% HPLC Package:1kg
• CB Index:58
• Related Information:Catalog(129)

• Company Name:HUBEI MICRO PHARMACEUTICAL
• Tel: 18627055345
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:99% Package:10g;100g；1000g
• CB Index:58
• Related Information:Catalog(67)

• Company Name:XI'AN VEDA CHEMICAL CO.,LTD
• Tel:+86-29-88665278 13379235092
• Products Intro:Product Name:Methotrexate
  CAS:59-05-2
  Purity:99% Package:1kg/RMB 1
• CB Index:58
• Related Information:Catalog(48)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Methotrexate hydrate, 99%
  CAS:59-05-2
  Purity:99% Package:1G;5G More...
• CB Index:76
• Related Information:Catalog(96815)