Rabeprazole Sodium
117976-90-6 Basic informationMore
- Product Name:Rabeprazole Sodium
- Synonyms: rebeprazole sodium sodium 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]benzoimidazole RABEPRAZOLE, SODIUM SALT 2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT 2-[[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL]SULFINY]-1H-BENZIMIDAZOLE SODIUM SALT Parie Rabeprazole-d4 SodiuM Salt Rabeprazole SoduiM
- CAS:117976-90-6
- MF:C18H21N3O3S.Na
- MW:382.43
- EINECS:629-730-3
- Mol File:117976-90-6.mol
USE
<p>Rebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric and duodenal ulcers. From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton after successive condensations. Rabeprazole, a structural analog of Omeprazole, the first compound to have been marketed in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ; a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml.<br>
Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and 20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory conditions including Zollinger-Ellison syndrome.</p>
<p>Rebeprazole sodium is White Crystalline Solid</p>
<p>Rebeprazole sodium is a partially reversible gastric proton pump inhibitor</p>
Lastest Price from Rabeprazole Sodium manufacturers
- Rabeprazole Sodium Enteric-Coated Capsules
- US $0.00 /Kg/Bag
- CAS:117976-90-6
- Min. Order: 2Kg/Bag
- Purity: GMP / DMF
- Supply Ability: 20 tons
- 2024-11-18
- Rebeprazole sodium
- US $0.00 /Kg/Drum
- CAS:117976-90-6
- Min. Order: 1KG
- Purity: Protein:90%
- Supply Ability: 20 TONS
- 2024-11-14
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Rabeprazole SodiuM Salt
CAS:117976-90-6
Purity:98.0%(LC) Package:100MG,1G More... - CB Index:76
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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- Products Intro:Product Name:Rebeprazole sodiuM
CAS:117976-90-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Chembest Research Laboratories Limited
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CAS:117976-90-6
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Rabeprazole Sodium Salt
CAS:117976-90-6
Purity:98.0% LC Package:100MG,1G More... - CB Index:81
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- Company Name:Beijing HwrkChemical Technology Co., Ltd
- Tel:010-89508211 18501085097
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CAS:117976-90-6
Purity:99.00% Package:1g Remarks:HWG17868 - CB Index:55
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