Homoharringtonine
26833-87-4 Basic informationMore
- Product Name:Homoharringtonine
- Synonyms: HOMOHARRINGTONIN HOMOHARRINGTONINE HHT cephalotaxine 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate CEPHALOTAXINE, 4-METHYL-2-HYDROXY-2-[4-HYDROXY-4-METHYLPENTYL] BUTANEDIOATE ESTER CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE 4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate(e cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa
- CAS:26833-87-4
- MF:C29H39NO9
- MW:545.63
- EINECS:
- Mol File:26833-87-4.mol
-
USE
The homoharringtonine is synthesized using δ-methyl-δ-caprolactone (1) and ethanol as starting materials via ring opening and elimination of ethyl 5-methyl-4-hexenoate (2), 2 has condensation reaction with diethyl oxalate to give diethyl 2-(3-methyl-2-butenyl) malonate (3), 3 has β-decarboxylation reaction with aqueous dimethylsulfoxide in the presence of sodium chloride to generate 6-methyl-2-oxo-5-heptenoic acid ethyl ester (4); 4 is subject to alkaline hydrolysis, oxalylation and further acylation of cephalotaxine to obtain 6-methyl-2-Oxo-5-heptenoic acid cephalomannine ester (6) and then subjected to a Rafalmacky reaction to give methyl 2-hydroxy-2-(4-methyl-3-pentenyl) succinate Cephalotaxine ester (7), 7 is subject to mercury hydroxylation and mercury removal reaction to obtain the end product, homoharringtonine. The reaction scheme is as follows:<br />
<img id="ProductImg2" src="/NewsImg/2016-11-23/2016112322285830349.png" alt="a chemical reaction route map for the laboratory synthesis of homoharringtonine" /><br />
Figure 2 is a chemical reaction route map for the laboratory synthesis of homoharringtonine.
Lastest Price from Homoharringtonine manufacturers
- Homoharringtonine
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- US $0.00-0.00/mg
- CAS:26833-87-4
- Min. Order: 20mg
- Purity: 98% HPLC
- Supply Ability: 100kg
- 2024-12-20
- Homoharringtonine
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- US $0.00 /Kg/Bag
- CAS:26833-87-4
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 100kg
- 2024-12-13
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- Company Name:Taihua Natural Bio-Pharmaceutical Co., Ltd.
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- CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:Homoharringtonine, 98%, from Taxus chinensis (Pilg.) Rehder
CAS:26833-87-4
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- Products Intro:Product Name:HoMoharringtonine;Cephalotaxine4-Methyl(2R)-2-hydroxy-2-(4-hydroxy-4-Methylpentyl)butanedioate
CAS:26833-87-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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CAS:26833-87-4
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CAS:26833-87-4
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- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
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- Products Intro:Product Name:Homoharringtonine
CAS:26833-87-4
Purity:98+% Remarks:E2023 More... - CB Index:64
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