Homoharringtonine

• Product Name:Homoharringtonine
• Synonyms: HOMOHARRINGTONIN HOMOHARRINGTONINE HHT cephalotaxine 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate CEPHALOTAXINE, 4-METHYL-2-HYDROXY-2-[4-HYDROXY-4-METHYLPENTYL] BUTANEDIOATE ESTER CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE 4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate(e cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa
• CAS:26833-87-4
• MF:C29H39NO9
• MW:545.63
• EINECS:
• Mol File:26833-87-4.mol
• 

The homoharringtonine is synthesized using &delta;-methyl-&delta;-caprolactone (1) and ethanol as starting materials via ring opening and elimination of ethyl 5-methyl-4-hexenoate (2), 2 has condensation reaction with diethyl oxalate to give diethyl 2-(3-methyl-2-butenyl) malonate (3), 3 has &beta;-decarboxylation reaction with aqueous dimethylsulfoxide in the presence of sodium chloride to generate 6-methyl-2-oxo-5-heptenoic acid ethyl ester (4); 4 is subject to alkaline hydrolysis, oxalylation and further acylation of cephalotaxine to obtain 6-methyl-2-Oxo-5-heptenoic acid cephalomannine ester (6) and then subjected to a Rafalmacky reaction to give methyl 2-hydroxy-2-(4-methyl-3-pentenyl) succinate Cephalotaxine ester (7), 7 is subject to mercury hydroxylation and mercury removal reaction to obtain the end product, homoharringtonine. The reaction scheme is as follows:<br /> <img id="ProductImg2" src="/NewsImg/2016-11-23/2016112322285830349.png" alt="a chemical reaction route map for the laboratory synthesis of homoharringtonine" /><br /> Figure 2 is a chemical reaction route map for the laboratory synthesis of homoharringtonine.

• Homoharringtonine
• 
• US $0.00-0.00/mg
• CAS:26833-87-4
• Min. Order: 20mg
• Purity: 98% HPLC
• Supply Ability: 100kg
• 2024-11-22

• Homoharringtonine
• 
• US $0.00 /Kg/Bag
• CAS:26833-87-4
• Min. Order: 1KG
• Purity: 98%min
• Supply Ability: 100kg
• 2024-11-21

• Company Name:Taihua Natural Bio-Pharmaceutical Co., Ltd.
• Tel:0914-7323168
• Products Intro:
• CB Index:58
• Related Information:Catalog(2)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Homoharringtonine, 98%, from Taxus chinensis (Pilg.) Rehder
  CAS:26833-87-4
  Purity:98% Package:5MG More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:HoMoharringtonine;Cephalotaxine4-Methyl(2R)-2-hydroxy-2-(4-hydroxy-4-Methylpentyl)butanedioate
  CAS:26833-87-4
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:HoMoharringtonine
  CAS:26833-87-4
  Remarks:C11098 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Adamas Reagent, Ltd.
• Tel:400-6009262 16621234537
• Products Intro:Product Name:Homoharringtonine
  CAS:26833-87-4
  Purity:对照品 Package:10mg~500mg Remarks:AC000148000 More...
• CB Index:59
• Related Information:Catalog(14103)

• Company Name:Shanghai Hanhong Scientific Co.,Ltd.
• Tel:021-54306202 13764082696
• Products Intro:Product Name:Homoharringtonine
  CAS:26833-87-4
  Purity:98+% Remarks:E2023 More...
• CB Index:64
• Related Information:Catalog(42958)