Eribulin
253128-41-5 Basic informationMore
- Product Name:Eribulin
- Synonyms: Eribulin B 1939 E 7389 ER 086526 US-DMF No. : 035118 DMF No. : 035118 Eribulin USP/EP/BP (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-Amino-2- hydroxypropyl]-21-methoxy-14-methyl-8,15-bis(methylene)-2,19,30,34,37,39,40,41-octaoxanonacyclo [24.9.2.1 3,32 .1 3,33 .1 6,9 .1 12,16 .0 18,22 .0 29,36 .0 31,35 ]hentetracontan-24-one
- CAS:253128-41-5
- MF:C40H59NO11
- MW:729.9
- EINECS:803-583-7
- Mol File:253128-41-5.mol
-
USE
The U.S. FDA approved eribulin mesylate (also referred to as E7389) in
November 2010 for the treatment of metastatic breast cancer (MBC) for
patients who previously received at least two chemotherapeutic regimens
for late-stage disease. Eribulin is a synthetic analog of the marine natural product halichondrin B, which is isolated from the sea sponge Halichondria okadai. Eribulin retains most of
the structural elements that constitute the right hand side of halichondrin
B; structure–activity relationship (SAR) studies suggested that the antitumor
activity of halichondrin B resides in that part of the molecule .
Eribulin is a microtubule inhibitor that binds close to the vinca-binding
site of tubulin. Unlike most tubulin inhibitors like taxanes, epothilones,
and vinca alkaloids that inhibit microtubule dynamic instability by changing
tubulin addition and loss parameters, eribulin’s effects on dynamic
instability are novel in that eribulin inhibits the growth phase of microtubules
without affecting the shortening phase by binding to microtubule
plus ends.
Lastest Price from Eribulin manufacturers
- Eribulin
-
- US $100.00 /KG
- CAS:253128-41-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 9000kg/per week
- 2023-04-23
- Eribulin
-
- US $12.00 /g
- CAS:253128-41-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5ton/Month
- 2021-11-27
Browse by Nationality 253128-41-5 Suppliers >Global suppliers
Beijing (5) Shanghai (26) Tianjin (2) Chongqing (1) Sichuan (3) Guangdong (7) Zhejiang (8) Hubei (30) Shandong (2) Shanxi (1) Henan (8) Hebei (3) Jilin (1) Anhui (2) Jiangsu (14) Jiangxi (2) Shaanxi (6) Hong Kong (2) Member (123) All (123)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.
- Tel:021-61001086 13671938079
- Products Intro:Product Name:Eribulin
CAS:253128-41-5
Purity:99%，单杂0.1%以下 Package:1g;10g;100g More... - CB Index:55
- Related Information:Catalog(100)
- Company Name:Hubei widely chemical technology Co., Ltd.
- Tel:027-83989310 18627915365
- Products Intro:Product Name:Brinzolamide
CAS:253128-41-5
Purity:99% Package:10mg/RMB 9000;100mg1000mg - CB Index:58
- Related Information:Catalog(1297)
- Company Name:Abydos Scientific
- Tel:025-84767922 18936879710
- Products Intro:Product Name:Eribulin
CAS:253128-41-5
Purity:0.99 Package:25kg，10kg，5kg，1kg More... - CB Index:58
- Related Information:Catalog(1029)
- Company Name:Nanjing Becas pharmatech Ltd.
- Tel: 13912903754
- Products Intro:Product Name:Eribulin
CAS:253128-41-5
Purity:0.99 Package:1g;5g - CB Index:58
- Related Information:Catalog(2257)
- Company Name:DebyeTec.com Inc.
- Tel:18086626237 18086626237
- Products Intro:Product Name:Trabectedin
CAS:253128-41-5
Purity:98+ Package:250mg - CB Index:56
- Related Information:Catalog(2643)
- Company Name:Chemvon Biotechnology Co., Ltd
- Tel:021-50790412
- Products Intro:Product Name:Eribulin
CAS:253128-41-5
Purity:99% HPLC Package:1g;50g;100g;1kg More... - CB Index:57
- Related Information:Catalog(371)
- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Eribulin (B1939
CAS:253128-41-5
Purity:98%+ HPLC Package:50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
- Related Information:Catalog(6011)