17-AAG
75747-14-7 Basic informationMore
- Product Name:17-AAG
- Synonyms: GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)- CP 127374 ALLYLAMINOGELDANAMYCIN NSC-330507 17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN 17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN 17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN 17-ALLYLAMINOGELDANAMYCIN
- CAS:75747-14-7
- MF:C31H43N3O8
- MW:585.69
- EINECS:
- Mol File:75747-14-7.mol
-
USE
Geldanamycin is a potent inhibitor of Hsp90 that exhibits severe hepatotoxicity when used in vivo. 17-AAG is an analog of geldanamycin which has potent in vivo activity and reduced toxicity. Like other Hsp90 inhibitors, 17-AAG has diverse anti-tumor actions and has potential in treating certain types of cancer. 17-AAG inhibits the growth of prostate cancer cell lines (IC50 = 25-45 nM). 17-AAG promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).
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