Imidafenacin
170105-16-5 Basic informationMore
- Product Name:Imidafenacin
- Synonyms: ONO 8025 Staybla Uritos 1H-IMidazole-1-butanaMide,2-Methyl-a,a-diphenyl- IMidafenacin DISCONTINUED-PATENTED PRODUCT 4-(2-METHYL-1H-IMIDAZOL-1-YL)-2,2-DIPHENYLBUTANAMIDE 2-Methyl-α,α-diphenyl-1H-iMidazole-1-butanaMide 4-(2-Methyl-1-iMidazolyl)-2,2- diphenylbutanaMide
- CAS:170105-16-5
- MF:C20H21N3O
- MW:319.4
- EINECS:689-703-7
- Mol File:170105-16-5.mol
-
USE
Imidafenacin, an M3/M1 muscarinic receptor antagonist, was introduced in
Japan for the oral treatment of OAB. The majority of OAB symptoms are
thought to result from overactivity of the detrusor muscle, which is primarily
mediated by acetylcholine-induced stimulation of muscarinic M3 receptors in the
bladder. Previously marketed muscarinic antagonists for OAB include propiverine,
tolterodine, oxybutynin, trospium, darifenacin, and solifenacin. In vitro,
imidafenacin is equally active against M1 and M3 receptors (K<sub>b</sub>＝0.32 and
0.55nM, respectively), and approximately 10-fold less active against M2 receptors
(K<sub>b</sub>＝4.13nM). <br/>Imidafenacin is chemically synthesized in three steps starting with alkylation of diphenylacetonitrile with dibromoethane, followed by condensation with 2-methylimidazole, and hydrolysis of the cyano group to a carboxamide group with 70% sulfuric acid.
Lastest Price from Imidafenacin manufacturers
- Imidafenacin
-
- US $20.00 /kg
- CAS:170105-16-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 2000kg
- 2024-06-28
- Imidafenacin
-
- US $10.00 /kg
- CAS:170105-16-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
- 2024-06-07
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:IMidafenacin DISCONTINUED-PATENTED PRODUCT
CAS:170105-16-5
Package:500Mg,50Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:IMidafenacin
CAS:170105-16-5
Remarks:C13761 More... - CB Index:61
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- Company Name:Adamas Reagent, Ltd.
- Tel:400-6009262 16621234537
- Products Intro:Product Name:Imidafenacin
CAS:170105-16-5
Purity:对照品 Package:10mg~500mg Remarks:AC001343000 - CB Index:59
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- Company Name:Hunan Hui Bai Shi Biotechnology Co., Ltd.
- Tel:0731-85526065 13308475853
- Products Intro:Product Name:Imidafenacin
CAS:170105-16-5
Purity:0.98 Package:100mg;500mg - CB Index:62
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- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:027-027-59207852 13308628970
- Products Intro:Product Name:Imidafenacin
CAS:170105-16-5
Purity:99% Package:1kg/ - CB Index:58
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