Canertinib dihydrochloride

• Product Name:Canertinib dihydrochloride
• Synonyms: CANERTINIB DIHYDROCHLORIDE N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride Canertinib.2HCL CI-1033 N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride Canertinib HCl CI 103
• CAS:289499-45-2
• MF:C24H27Cl3FN5O3
• MW:558.86
• EINECS:
• Mol File:289499-45-2.mol
• 

<p>The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors.Canertinib dihydrochloride is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib dihydrochloride also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.</p>

• Canertinib dihydrochloride
• 
• US $0.00 /kg
• CAS:289499-45-2
• Min. Order: 1kg
• Purity: 0.99
• Supply Ability: 20tons
• 2024-08-15

• Canertinib dihydrochloride
• 
• US $23.00 /KG
• CAS:289499-45-2
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 1 ton
• 2022-09-01

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Canertinib 2HCL
  CAS:289499-45-2
  Remarks:C13434 More...
• CB Index:61
• Related Information:Catalog(6008)

• Company Name:Shanghai Longsheng chemical Co.,Ltd.
• Tel:021-58099652-8005 13585536065
• Products Intro:Product Name:Canertinib dihydrochloride
  CAS:289499-45-2
  Purity:98% More...
• CB Index:59
• Related Information:Catalog(9816)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:Canertinib dihydrochloride
  CAS:289499-45-2
  Purity:>99%,BR Package:50MG Remarks:2800 More...
• CB Index:58
• Related Information:Catalog(4672)