HERBIMYCIN A
70563-58-5 Basic informationMore
- Product Name:HERBIMYCIN A
- Synonyms: HERBIMYCIN A HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS HERBIMYCIN A, STREPTOMYCES SPECIES herbimycin A from streptomyces hygros-copicus herbimycin A from streptomyces*hygroscopicus Herbimycin A, Streptomyces sp. C11225 [(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)-2,5,6,11-Tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl]carbamate
- CAS:70563-58-5
- MF:C30H42N2O9
- MW:574.66
- EINECS:
- Mol File:70563-58-5.mol
-
USE
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:HerbiMycin A;(15R)-17-deMethoxy-15-Methoxy-11-O-Methyl-geldanaMycin
CAS:70563-58-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:Herbimycin A
CAS:70563-58-5
Purity:95% Package:0.1mg/RMB 2421.90;0.5mg/RMB 5148.90 More... - CB Index:65
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- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:Herbimycin A from Streptomyces hygroscopicus
CAS:70563-58-5
Purity:95% (HPLC) Package:5MG; 25MG; 100MG; 1G More... - CB Index:55
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- Company Name:Codow Chemical Co.,Ltd.
- Tel: 18620099427
- Products Intro:Product Name:Herbimycin A from Streptomyces hygroscopicus
CAS:70563-58-5
Purity:0.95 Package:1MG More... - CB Index:55
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Herbimycin A
CAS:70563-58-5
Purity:99% Package:100μg;500μg;1mg - CB Index:58
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- Company Name:Shandong Xiya Chemical Co., Ltd.
- Tel:4009903999 13395398332
- Products Intro:CAS:70563-58-5
Purity:>=95.0% Package:0.1mg;0.5mg - CB Index:60
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- Company Name:Chengdu Dianchun Technology Co., Ltd
- Tel:400-1166-196 18502815961
- Products Intro:Product Name:Herbimycin A from Streptomyces hygroscopicus
CAS:70563-58-5
Purity:99% HPLC Package:10g;50g;100g;500g;1kg;5kg;25kg More... - CB Index:60
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