JASPLAKINOLIDE
102396-24-7 Basic informationMore
- Product Name:JASPLAKINOLIDE
- Synonyms: JASPLAKINOLIDE JASPLAKINOLIDE, JASPIS JOHNSTONI (3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone [3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone NSC 613009 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl] GQWYWHOHRVVHAP-DHKPLNAMSA-N
- CAS:102396-24-7
- MF:C36H45BrN4O6
- MW:709.67
- EINECS:
- Mol File:102396-24-7.mol
-
USE
Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC50 = 35 nM) by binding F-actin (KD = 15 nM). This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo. This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.
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- Company Name:J & K SCIENTIFIC LTD.
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Package:100μg,50μg More... - CB Index:76
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Purity:>=97% (HPLC) Package:100μg/RMB 6179.90 More... - CB Index:65
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- Company Name:Shanghai Tauto Biotech Co., Ltd.
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CN2-0037-C100 More... - CB Index:66
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- Company Name:ChemStrong Scientific Co.,Ltd
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Purity:95% HPLC Package:10mg;25mg;50mg;100mg More... - CB Index:56
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- Company Name:Sigma-Aldrich
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Purity:>=97% (HPLC) Package:100UG Remarks:J4580-100UG More... - CB Index:80
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
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- Products Intro:Product Name:Jasplakinolide
CAS:102396-24-7
Purity:98% (HPLC) Package:50ug;100ug - CB Index:58
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