Atazanavir

• Product Name:Atazanavir
• Synonyms: atazanvir Atazanavir, >=99% Atazanavir Enantiomer Atazanavir Isomer Impurity Atazanavir Isomer Impurity 1 Atazanavir Isomer Impurity 2 Atazanavir Isomer Impurity 3 Atazanavir Intermediate Impurity 1
• CAS:198904-31-3
• MF:C38H52N6O7
• MW:704.86
• EINECS:812-543-8
• Mol File:198904-31-3.mol
• 

Atazanavir is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease, an enzyme that is essential for the processing of Gag and Gag-Pol polyproteins into structural and enzymatic proteins required for viral replication. It has a similar pharmacophore motif to the other six widely marketed HIV protease inhibitors, most of which are based upon a hydroxyethylamine template. Uniquely, it possesses an aza-peptide motif but maintains many similar pharmacophore elements including lipophilic moieties that presumably bind to S₂, S₁, S′₁ , and S′₂ positions. Atazanavir is pseudo-symmetric about the central template, incorporating D-tert-Leucine at both termini. This compound is synthesized in about seven steps, with a key coupling of the chiral epoxide (derived from phenylalanine and imparting one chiral center) and N-tert-boc-N′-(4-[2-pyridyl]benzyl)hydrazine. Removal of both tert-Boc groups and double acylation with methoxycarbonyl-tert-Leucine provides the product. Another synthesis of atazanavir entails ten steps and utilizes α-(tert-bocamino) phenylpropanal as a chiral intermediate. It is a potent inhibitor of indinavir-resistant and saquinavir-resistant strains of HIV-1 (IC₅₀=0.03–0.1 and 0.04–0.1 μM, respectively). In 300 patients who had failed previous treatment, atazanavir (400 mg once daily) was compared to lopinavir (400 mg twice daily) and ritonavir (100 mg); both arms additionally receiving two non-reverse transcriptase inhibitors. After 24 weeks, HIV RNA levels of ＜400 copies/mL were noted in 61% of patients receiving atazanavir and 81% of those taking lopinavir/ritonavir. After 96 weeks of therapy with atazanavir, HIV RNA copy levels were found to be ＜400 and ＜50 in 80 and 58% of patients, respectively. A study of the cross-resistance profile relative to other protease inhibitors using a panel of 551 clinical isolates (without prior atazanavir exposure but with cross-resistance to one or two other protease inhibitors; the majority had resistance to nelfinavir) showed that greater than 80% retained susceptibility to atazanavir. All of the resistant isolates from patients taking atazanavir had an I50 L substitution. The recommended dosage of atazanavir is 400 mg once daily. It has a mean half-life range of 7.9–6.5 h with about 60% bioavailability and moderate plasma protein binding (86% albumin and 89% alpha-1- acid glycoprotein (AAG)). Atazanavir was well tolerated in clinical studies and it displayed minimal lipid modulation when tested in combination with two non-reverse transcriptase inhibitors. Atazanavir had no effect on total cholesterol, low-density lipoprotein, and triglyceride levels when compared with other protease inhibitors that caused sustained elevations in these lipid levels.

• Atazanavir
• 
• US $0.00 /Kg/Bag
• CAS:198904-31-3
• Min. Order: 1KG
• Purity: 99%min
• Supply Ability: 100KGS
• 2025-01-20

• Atazanavir
• 
• US $0.00-0.00/KG
• CAS:198904-31-3
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 500000kg
• 2024-11-04

• Company Name:Jiangxi ravel Biotechnology Co.,Ltd
• Tel: 18502762009
• Products Intro:Product Name:Atazanavir
  CAS:198904-31-3
  Purity:98%HPLC Package:1kg/
• CB Index:58
• Related Information:Catalog(2448)

• Company Name:Mancinor Technology Co., Ltd.
• Tel: 19719236623
• Products Intro:Product Name:198904-31-3
  CAS:198904-31-3
  Purity:97%+ Package:1g；1kg；25kg
• CB Index:58
• Related Information:Catalog(956)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Atazanavir
  CAS:198904-31-3
  Package:50Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Atazanavir
  CAS:198904-31-3
  Purity:98% Package:100mg;500mg;1g;5g;10g Remarks:C13331 More...
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Adamas Reagent, Ltd.
• Tel:400-6009262 16621234537
• Products Intro:Product Name:Atazanavir
  CAS:198904-31-3
  Purity:对照品 Package:10mg~500mg Remarks:AC000490000 More...
• CB Index:59
• Related Information:Catalog(14103)

• Company Name:Nanjing Chemlin Chemical Co., Ltd
• Tel:025-83697070
• Products Intro:Product Name:Atazanavir
  CAS:198904-31-3
  Purity:98% Package:1mg; 5mg; 50mg; 500mg; 5g; 50g More...
• CB Index:64
• Related Information:Catalog(19183)