BI-6C9
791835-21-7 Basic informationMore
- Product Name:BI-6C9
- Synonyms: N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide Butanamide, N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]- N-(4-((4-Aminophenyl)thio)phenyl)-4-(4-methoxyphenylsulfonamido)butanamide Inhibitor,fission,Neurodegeneration,Bid,BI6C9,BI 6C9,Mitochodondrial,death,Mitochondria,Apoptosis,inhibit,Glutamate,stress,Neuronal,Bcl-2,Mitochondrial,Mitochondrial Metabolism,potential,cell,Oxidative,membrane,BI-6C9,BI-6C-9
- CAS:791835-21-7
- MF:C23H25N3O4S2
- MW:471.59
- EINECS:
- Mol File:791835-21-7.mol
-
USE
BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:BI-6C9
CAS:791835-21-7
Purity:98% Package:1mg;2mg;5mg More... - CB Index:58
- Related Information:Catalog(9806)
- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 18892239720
- Products Intro:Product Name:BI-6C9
CAS:791835-21-7
Purity:98% Package:5mg;10mg;50mg - CB Index:58
- Related Information:Catalog(12308)
- Company Name:MedBioPharmaceutical Technology Inc
- Tel:021-69568360 18916172912
- Products Intro:Product Name:BI-6C9
CAS:791835-21-7
Purity:98% Package:1mg; 10mg; 5mg Remarks:Medbio - CB Index:58
- Related Information:Catalog(8141)
- Company Name:Nantong Hi-Future Biotechnology Co., Ltd
- Tel: 18051384581
- Products Intro:Product Name:BI-6C9
CAS:791835-21-7
Purity:98% HPLC Package:100mg，500mg，1g，5g，10g - CB Index:58
- Related Information:Catalog(3057)
- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 15801484223;
- Products Intro:Product Name:BI-6C9
CAS:791835-21-7
Purity:98% Package:5mg;10mg;50mg - CB Index:58
- Related Information:Catalog(29778)