T0901317
293754-55-9 Basic informationMore
- Product Name:T0901317
- Synonyms: N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE T0901317 TO-901317 BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]- T 1317 T0901317;T 0901317; T-0901317 N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl] T0901317 - CAS 293754-55-9 - Calbiochem
- CAS:293754-55-9
- MF:C17H12F9NO3S
- MW:481.33
- EINECS:
- Mol File:293754-55-9.mol
-
USE
The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.
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- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 18892239720
- Products Intro:Product Name:T0901317
CAS:293754-55-9
Purity:98% (HPLC) Package:25mg;100mg;1g More... - CB Index:58
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:T 0901317;N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]benzenesulfonaMide
CAS:293754-55-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:T0901317
CAS:293754-55-9
Purity:>98%,LXRFXR Package:25MG;100MG; - CB Index:58
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:T0901317
CAS:293754-55-9
Purity:>=98% Package:100mg/RMB 1400.90;25mg/RMB 699.90;10mg/RMB 429.90 More... - CB Index:65
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- Company Name:TargetMol Chemicals Inc.
- Tel:021-021-33632979 15002134094
- Products Intro:Product Name:T0901317
CAS:293754-55-9
Purity:99.58% Package:5mg/RMB 297;10mg/RMB 477;25mg/RMB 758 More... - CB Index:58
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- Products Intro:Product Name:Tiplaxtinin(PAI-039)
CAS:293754-55-9
Purity:98% Package:1g;10g;100g - CB Index:58
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- Company Name:Shanghai Hekang Biotechnology Co., Ltd.
- Tel: 18939837085
- Products Intro:Product Name:T0901317
CAS:293754-55-9
Purity:98+% Package:1g, 5g, 10g, 25g, 100g, 1kg, 1000kg Remarks:C7958 More... - CB Index:55
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