Eggmanone
505068-32-6 Basic informationMore
- Product Name:Eggmanone
- Synonyms: Eggmanone 3-(2-methylprop-2-enyl)-2-(2-oxo-2-thiophen-2-ylethyl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one [1]Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-
- CAS:505068-32-6
- MF:C20H20N2O2S3
- MW:416.58
- EINECS:
- Mol File:505068-32-6.mol
-
USE
Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers. Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway. It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 μM, respectively). Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.[Cayman Chemical]
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Eggmanone
CAS:505068-32-6
Purity:98% Package:1mg;5mg;10mg More... - CB Index:58
- Related Information:Catalog(9806)
- Company Name:MedBioPharmaceutical Technology Inc
- Tel:021-69568360 18916172912
- Products Intro:Product Name:Eggmanone
CAS:505068-32-6
Purity:98% Package:50mg; 10mg Remarks:Medbio - CB Index:58
- Related Information:Catalog(8140)
- Company Name:TargetMol Chemicals Inc.
- Tel: 4008200310
- Products Intro:Product Name:Eggmanone
CAS:505068-32-6
Package:10mg/RMB 11000;5mg/RMB 6230;1mg/RMB 1410 - CB Index:58
- Related Information:Catalog(24647)
- Company Name:Nantong QuanYi Biotechnology Co., Ltd
- Tel:0513-66337626 18051384581
- Products Intro:Product Name:Eggmanone
CAS:505068-32-6
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more - CB Index:58
- Related Information:Catalog(4933)
- Company Name:Shanghai Hao Zhun Biological Technology Co., Ltd.
- Tel: 15800340161
- Products Intro:Product Name:Eggmanone
CAS:505068-32-6
Purity:95% - CB Index:58
- Related Information:Catalog(6650)