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PASIREOTIDE

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396091-73-9 Basic informationMore
USE
In April 2012, the European Commission approved pasireotide for the treatment of Cushing’s Disease (CD) in adult patients who have not responded to surgical interventionor forwhomsurgery is not anoption.Pasireotide was approved for the same indication by the US FDA in December of 2012. Pasireotide (also known as SOM230) is a cyclohexapeptide that acts as a somatostatin analogue to inhibit the release of ACTH. Somatostatins are cyclic peptides of 14 and 28 amino acids that play animportant role inregulating endocrineandexocrine release inmany tissues through an inhibitory mechanism. There are five known subtypes of somatostatin receptors (SSTRs). Natural somatostatins bind with high affinity to all five subtypes, however, their therapeutic use is limited by rapid degradation in plasma. Pasireotide arose fromefforts to identify a somatostatinmimetic with long-lasting inhibitory effects. Starting with a 14-amino acid somatostatin peptide, a systematic alanine scan revealed residues that were essential for receptor sub-type binding, including key b-turn regions and adjacent residues. Placing the key structural elements as unnatural amino acids in a cyclohexapeptide backbone gave pasireotide.
Lastest Price from PASIREOTIDE manufacturers
  • Pasireotide
  • US $0.00 /g
  • CAS:396091-73-9
  • Min. Order: 1g
  • Purity: 98%min
  • Supply Ability: 1000g
  • 2024-07-23
  • PASIREOTIDE
  • US $70.00-700.00/kg
  • CAS:396091-73-9
  • Min. Order: 10kg
  • Purity: 0.99
  • Supply Ability: 20tons
  • 2024-05-10

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  • Company Name:Hangzhou Peptidego Biotech Co.,Ltd.
  • Tel:0571-87213919
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:98% Package:1g;5g;10g;50g;100g or according to customer's detail requirement. More...
  • CB Index:58
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  • Company Name:Hangzhou Peptide Biochem Co.,Ltd
  • Tel:0571-89197072; 18668118770
  • Products Intro:Product Name:pasireotide
    CAS:396091-73-9
    Purity:95%;98%,99%HPLC Package:1mg;5mg;10mg;50mg;100mg;1g;10g Remarks:ISO,GMP,FDA More...
  • CB Index:56
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  • Company Name:Hangzhou Go Top Peptide Biotech
  • Tel:0571-88211921 13355716090
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:98% Package:1克/瓶/RMB 30;5克/瓶/RMB 150;20克/瓶/RMB 600
  • CB Index:58
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  • Company Name:Nanchang Tianzhen Biotechnology Co., Ltd
  • Tel: 13173652190
  • Products Intro:Product Name:PASIREOTIDE
    CAS:396091-73-9
    Purity:98% Package:5mg/RMB 1000;25mg100mg
  • CB Index:58
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  • Company Name:Apextide Co Ltd
  • Tel: 15300650552
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:>99.0% HPLC Package:10mg;1g;10g;100g
  • CB Index:58
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  • Company Name:Nanjing Yuanpeptide Biotech Co.,Ltd.
  • Tel: 18168071971
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:95% HPLC 98% HPLC 99% HPLC Package:10mg;20mg;50mg;100mg;1g;5g;20g
  • CB Index:58
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  • Company Name:Alabiochem Tech.Co., Ltd.
  • Tel:0512-58900862 400-0707518
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:99% Package:25mg; 50mg;250mg;Bulk Remarks:B0343
  • CB Index:59
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  • Company Name:ChemStrong Scientific Co.,Ltd
  • Tel:0755-0755-66853366 13670046396
  • Products Intro:Product Name:Pasireotide
    CAS:396091-73-9
    Purity:95% HPLC Package:10mg;25mg;50mg;100mg
  • CB Index:56
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