GNE 7915

• Product Name:GNE 7915
• Synonyms: GNE 7915 [4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone GNE-7915, >=98% (4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol (4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone CS-1279 GNE7915; GNE 7915 Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
• CAS:1351761-44-8
• MF:C19H21F4N5O3
• MW:443.4
• EINECS:
• Mol File:1351761-44-8.mol
• 

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

• Company Name:Suzhou Chenrui Biotechnology Co. LTD
• Tel: 17625585511
• Products Intro:Product Name: GNE7915
  CAS:1351761-44-8
  Purity:98% Package:1g/;5g/;10g/
• CB Index:58
• Related Information:Catalog(650)

• Company Name:Nanjing Habo Medical Technology Co., Ltd.
• Tel:025-85760892 13376090521
• Products Intro:Product Name:GNE7915
  CAS:1351761-44-8
  Purity:0.97 Package:大货，可根据客户需求包装
• CB Index:60
• Related Information:Catalog(970)

• Company Name:Hangzhou J&H Chemical Co., Ltd.
• Tel:0571-+86-571-87396432
• Products Intro:Product Name:GNE-7915
  CAS:1351761-44-8
  Purity:99% Package:1g;1kg,100kg,1000kg
• CB Index:59
• Related Information:Catalog(11578)