Abemaciclib mesylate (LY2835219)
1231930-82-7 Basic informationMore
- Product Name:Abemaciclib mesylate (LY2835219)
- Synonyms: 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-, methanesulfonate (1:1) N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine methanesulfonate (1:1) LY2835219 LY2835219 mesylate Bemaciclib(salt) N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine,methanesulfonic acid N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methyle LY2835219 Ms salt, Abemaciclib Ms salt
- CAS:1231930-82-7
- MF:C28H36F2N8O3S
- MW:602.71
- EINECS:
- Mol File:1231930-82-7.mol
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USE
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.[Cayman Chemical]
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:N-[5-[(4-Ethyl-1-piperazinyl)Methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-Methyl-1-(1-Methylethyl)-1H-benziMidazol-6-yl]-2-pyriMidinaMine Methanesulfonate
CAS:1231930-82-7
Package:2.5Mg,25Mg More... - CB Index:76
- Related Information:Catalog(94657)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Abemaciclib mesylate(LY2835219 mesylate)
CAS:1231930-82-7
Purity:98%+ HPLC Package:50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:BeiJing Hwrk Chemicals Limted
- Tel:0757-86329057 18934348241
- Products Intro:Product Name:LY2835219
CAS:1231930-82-7
Purity:98.00% Package:1g Remarks:HWG49941 More... - CB Index:55
- Related Information:Catalog(14063)
- Company Name:Shanghai Hanhong Scientific Co.,Ltd.
- Tel:021-54306202 13764082696
- Products Intro:Product Name:N-(5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate
CAS:1231930-82-7
Purity:98% Remarks:GN0104723 More... - CB Index:64
- Related Information:Catalog(42958)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:LY2835219
CAS:1231930-82-7
Purity:>99%,BR Package:10mg;50mg;500mg Remarks:MC8035 More... - CB Index:58
- Related Information:Catalog(4727)