AST 487
630124-46-8 Basic informationMore
- Product Name:AST 487
- Synonyms: AST 487 NVP-AST 487 1-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-(4-{[6-(methylamino)-4-pyrimidinyl]oxy}phenyl)urea 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea AST487 (NVP- AST487) N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea Urea,N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]- CS-562
- CAS:630124-46-8
- MF:C26H30F3N7O2
- MW:529.56
- EINECS:205-525-8
- Mol File:630124-46-8.mol
-
USE
AST-487 is an inhibitor of RET (IC50 = 0.88 μM), FLT3 (Ki = 0.52 μM), KDR (IC50 = 0.17 μM), c-Abl (IC50 = 0.02 μM), and c-Kit (IC50 = 0.5 μM). It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.[Cayman Chemical]
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- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:AST487
CAS:630124-46-8
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g - CB Index:55
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- Company Name:Shanghaizehan biopharma technology co., Ltd.
- Tel:021-61350663 13052117465
- Products Intro:Product Name:AST487
CAS:630124-46-8
Purity:98% Package:1g/;5g/ - CB Index:55
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- Company Name:ATK CHEMICAL COMPANY LIMITED
- Tel:021-51619050 13301662590
- Products Intro:CAS:630124-46-8
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G More... - CB Index:55
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:AST 487
CAS:630124-46-8
Purity:95.00% Package:1mg;2mg;5mg More... - CB Index:58
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