ATB-337

• Product Name:ATB-337
• Synonyms: ATB-337 ACS 15 S-Diclofenac BRDUXOHVEZVAHI-UHFFFAOYSA-N Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
• CAS:912758-00-0
• MF:C23H15Cl2NO2S3
• MW:504.47
• EINECS:
• Mol File:912758-00-0.mol
• 

Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity. Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac. In rats, diclofenac at 10-50 μmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 μmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-α, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 μmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.[Cayman Chemical]

• Company Name:MedBioPharmaceutical Technology Inc
• Tel:021-69568360 18916172912
• Products Intro:Product Name:ATB-337
  CAS:912758-00-0
  Purity:98% Package:10mg; 50mg; 5mg Remarks:Medbio
• CB Index:58
• Related Information:Catalog(8141)

• Company Name:InvivoChem
• Tel: 13549236410
• Products Intro:Product Name:S-Diclofenac
  CAS:912758-00-0
  Purity:>=98% Package:98% Remarks:V14565
• CB Index:58
• Related Information:Catalog(6712)

• Company Name:TargetMol Chemicals Inc.
• Tel: 4008200310
• Products Intro:Product Name:ATB-337
  CAS:912758-00-0
  Purity:98% Package:100 mg；5 mg；50 mg
• CB Index:58
• Related Information:Catalog(24024)

• Company Name:Shanghai Yifei Biotechnology Co. , Ltd.
• Tel:021-65675885 18964387627
• Products Intro:Product Name:ATB-337
  CAS:912758-00-0
  Purity:98% Package:1mg;5mg;10mg
• CB Index:58
• Related Information:Catalog(8740)

• Company Name:Hangzhou MolCore BioPharmatech Co.,Ltd.
• Tel:+86-057181025280; +8617767106207
• Products Intro:Product Name:ACS 15
  CAS:912758-00-0
  Purity:NLT 98% Remarks:MC579419
• CB Index:58
• Related Information:Catalog(49739)

• Company Name:Beijing Fubo Biotechnology Co., Ltd.
• Tel:010-57263844 13260236521
• Products Intro:Product Name:ATB-337
  CAS:912758-00-0
  
• CB Index:58
• Related Information:Catalog(6039)

• Company Name:Shanghai Jingke Chemical Technology Co., Ltd.
• Tel:021-54997581 13524423207
• Products Intro:Product Name:ATB-337
  CAS:912758-00-0
  
• CB Index:58
• Related Information:Catalog(6974)