ATB-337
912758-00-0 Basic informationMore
- Product Name:ATB-337
- Synonyms: ATB-337 ACS 15 S-Diclofenac BRDUXOHVEZVAHI-UHFFFAOYSA-N Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester
- CAS:912758-00-0
- MF:C23H15Cl2NO2S3
- MW:504.47
- EINECS:
- Mol File:912758-00-0.mol
-
USE
Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity. Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac. In rats, diclofenac at 10-50 μmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 μmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-α, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 μmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.[Cayman Chemical]
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- Products Intro:Product Name:ATB-337
CAS:912758-00-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g - CB Index:58
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Purity:98% Package:10mg; 50mg; 5mg Remarks:Medbio - CB Index:58
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CAS:912758-00-0
Purity:98% HPLC Package:1mg Remarks:V14565 - CB Index:58
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- Company Name:Shanghai Yifei Biotechnology Co. , Ltd.
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CAS:912758-00-0
Purity:98.00% Package:1mg;5mg;10mg - CB Index:58
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CAS:912758-00-0
Package:1mg/RMB 630;5mg/RMB 2710;10mg/RMB 4790 - CB Index:58
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CAS:912758-00-0
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- Products Intro:Product Name:ATB-337
CAS:912758-00-0
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