DBeQ
177355-84-9 Basic informationMore
- Product Name:DBeQ
- Synonyms: DBeQ 2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)- 2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)- JRF 12 N,N'-Dibenzylquinazoline-2,4-diamine N2,N4-Dibenzylquinazoline-2,4-diamine JRF N,N'-Dibenzylquinazoline-2,4-diamine DBeQ
- CAS:177355-84-9
- MF:C22H20N4
- MW:340.42
- EINECS:
- Mol File:177355-84-9.mol
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USE
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:DBeQ
CAS:177355-84-9
Purity:>98%,BR Package:100MG Remarks:3380 More... - CB Index:58
- Related Information:Catalog(4727)
- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:DBeQ
CAS:177355-84-9
Purity:98% Package:1G; 5G; 25G; 100G; 1KG; 5KG More... - CB Index:55
- Related Information:Catalog(4674)