PF 477736
952021-60-2 Basic informationMore
- Product Name:PF 477736
- Synonyms: PF 477736 PF-00477736 PF-736 (αR)-α-AMino-N-[5,6-dihydro-2-(1-Methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetaMide PF 477736(PF-0044736) (2R)-2-aMino-2-cyclohexyl-N-[2-(1-Methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7,11-pentaen-6-yl]acetaMide PF0044736 PF-0044736
- CAS:952021-60-2
- MF:C22H25N7O2
- MW:419.49
- EINECS:
- Mol File:952021-60-2.mol
-
USE
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.[Cayman Chemical]
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- Company Name:Shanghai Changyan Chem & Tech Co., Ltd.
- Tel:021-20242659 18930833303
- Products Intro:Product Name:PF-477736
CAS:952021-60-3
Purity:95% HPLC Package:5KG;1KG;500G;100G;50G More... - CB Index:55
- Related Information:Catalog(5010)
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:PF 477736
CAS:952021-60-2
Package:100Mg,10Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:PF 477736(PF-0044736)
CAS:952021-60-2
Remarks:C14005 More... - CB Index:61
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:PF 477736
CAS:952021-60-2
Purity:>98% Package:50MG Remarks:4380 More... - CB Index:58
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel:400-400-6206333 18521732826
- Products Intro:Product Name:PF-477736
CAS:952021-60-2
Purity:98% Package:25mg/RMB 3295.90;5mg/RMB 882.90 More... - CB Index:65
- Related Information:Catalog(25003)