A77 1726

• Product Name:A77 1726
• Synonyms: A 1726 HMR 1726 (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide LeflunoMide EP IMpurity B Leflunomide Impurity 2(Leflunomide EP Impurity B) A-771726;A 771726;A771726 A-771726;A 77-1726;A771726;HMR-1726 (2Z)-2-Cyano-3-hydroxy-N-[4-(triflu
• CAS:163451-81-8
• MF:C12H9F3N2O2
• MW:270.21
• EINECS:642-273-4
• Mol File:163451-81-8.mol
• 

A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0/G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-α and IL-1α (IC50s = 7 and 3 μM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 μM.[Cayman Chemical]

• Teriflunomide
• 
• US $0.00 /g
• CAS:163451-81-8
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2024-12-23

• Teriflunomide
• 
• US $0.00-0.00/Kg/Drum
• CAS:163451-81-8
• Min. Order: 1KG
• Purity: 98%min
• Supply Ability: 1000KGS
• 2024-12-13

• Company Name:Jiangxi ravel Biotechnology Co.,Ltd
• Tel:400-880-2824 18107960669
• Products Intro:Product Name:teriflunomide
  CAS:163451-81-8
  Purity:99 Package:1kg/
• CB Index:58
• Related Information:Catalog(1267)

• Company Name:Hubei Hicks Biochemical Co., Ltd
• Tel:17362916295; 17362916295
• Products Intro:Product Name:teriflunomide
  CAS:163451-81-8
  Purity:99% HPLC Package:5KG;1KG
• CB Index:58
• Related Information:Catalog(4006)

• Company Name:SiChuang NanBu Honesty Technology Co., Ltd.
• Tel:0838-5675166 15883665058
• Products Intro:Product Name:A77 1726
  CAS:163451-81-8
  Package:1kg/
• CB Index:55
• Related Information:Catalog(668)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:A77 1726
  CAS:163451-81-8
  Package:100Mg,10Mg,1g,25Mg More...
• CB Index:76
• Related Information:Catalog(94657)

• Company Name:TCI (Shanghai) Development Co., Ltd.
• Tel:021-67121386
• Products Intro:Product Name:Teriflunomide
  CAS:163451-81-8
  Purity:98.0% GC Package:100MG,1G More...
• CB Index:81
• Related Information:Catalog(24529)

• Company Name:Adamas Reagent, Ltd.
• Tel:400-6009262 16621234537
• Products Intro:Product Name:Teriflunomide
  CAS:163451-81-8
  Purity:对照品 Package:10mg~500mg Remarks:AC000163000
• CB Index:59
• Related Information:Catalog(14103)

• Company Name:Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd
• Tel: 18901358086
• Products Intro:Product Name:TeriflunoMide
  CAS:163451-81-8
  Purity:99.5% More...
• CB Index:57
• Related Information:Catalog(56)