N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
315703-52-7 Basic informationMore
- Product Name:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Synonyms: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Hh Signaling Antagonist VII, JK184 JK 184 N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine 2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)- Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem CS-2369 JK184 (JK-184
- CAS:315703-52-7
- MF:C19H18N4OS
- MW:350.44
- EINECS:
- Mol File:315703-52-7.mol
-
USE
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:JK 184;N-(4-Ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-2-thiazolaMine
CAS:315703-52-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15848)
- Company Name:AdooQ Bioscience CHINA
- Tel:025-58849295 18951903616;
- Products Intro:Product Name:JK 184
CAS:315703-52-7
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg More... - CB Index:60
- Related Information:Catalog(2989)
- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:CAS:315703-52-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G More... - CB Index:55
- Related Information:Catalog(4197)
- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:JK 184
CAS:315703-52-7
Purity:99% (HPLC) Package:1mg;5mg;10mg - CB Index:58
- Related Information:Catalog(9708)