VX 702
745833-23-2 Basic informationMore
- Product Name:VX 702
- Synonyms: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702 VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX702;VX-702 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide (479543-46-9) vx 702 CS-1840
- CAS:745833-23-2
- MF:C19H12F4N4O2
- MW:404.32
- EINECS:
- Mol File:745833-23-2.mol
-
USE
VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.[Cayman Chemical]
Lastest Price from VX 702 manufacturers
- VX 702
-
- US $100.00 /KG
- CAS:745833-23-2
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 50000kg/Month
- 2023-08-16
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:VX-702
CAS:745833-23-2
Package:50Mg,5Mg More... - CB Index:76
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- Company Name:ZHIWE CHEMTECH CO LTD
- Tel:021-20221225 13917446399
- Products Intro:Product Name:VX-702
CAS:745833-23-2
Purity:98% More... - CB Index:61
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:VX-702
CAS:745833-23-2
Remarks:C14341 More... - CB Index:61
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:VX 702
CAS:745833-23-2
Purity:>98%,p38α MAPK Package:10MG More... - CB Index:58
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