α-Naphthoflavone
604-59-1 Basic informationMore
- Product Name:α-Naphthoflavone
- Synonyms: 7,8-BENZOFLAVONE ALPHA-NAPHTHOFLAVONE A-NAPHTHOFLAVANONE A-NAPHTHOFLAVONE BENZOFLAVONE NAPHTHOFLAVANONE, A- NAPHTHOFLAVONE, A- 2-b)pyran-4-one,2-phenyl-4h-naphtho(
- CAS:604-59-1
- MF:C19H12O2
- MW:272.3
- EINECS:210-071-1
- Mol File:604-59-1.mol
-
USE
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
Lastest Price from α-Naphthoflavone manufacturers
- α-Naphthoflavone
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- US $0.00-0.00/kg
- CAS:604-59-1
- Min. Order: 1kg
- Purity: 98.0%
- Supply Ability: 1kg/month
- 2024-12-13
- α-Naphthoflavone
-
- US $0.00 /kg
- CAS:604-59-1
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20 tons
- 2024-10-25
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- Company Name:SHANDONG XINGRUNDA CHEMICAL CO.,LTD
- Tel:18615348689 18615348689
- Products Intro:Product Name:α-Naphthoflavone
CAS:604-59-1
Purity:99%HPLC Package:1kg/RMB 3500;25kg - CB Index:58
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- Company Name:Lihe Biotechnology (Shandong) Co., Ltd
- Tel:15588824841 15588824841
- Products Intro:Product Name:α-Naphthoflavone
CAS:604-59-1
Purity:99% Package:10g;1kg;5kg - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:α-Naphthoflavone, 98%
CAS:604-59-1
Purity:98% Package:1G;25G;5G More... - CB Index:76
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- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:021-61259108 18621169109
- Products Intro:Product Name:alpha-Naphthoflavone
CAS:604-59-1
Purity:99.5+% Remarks:12816 More... - CB Index:62
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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- Products Intro:Product Name:ALPHA-NAPHTHOFLAVONE
CAS:604-59-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:alpha-Naphthoflavone
CAS:604-59-1
Purity:98.0% LC Package:1G,5G More... - CB Index:81
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- Company Name:Energy Chemical
- Tel:021-021-58432009 400-005-6266
- Products Intro:Product Name:ALPHA-NAPHTHOFLAVONE
CAS:604-59-1
Purity:97% Package:25g,5g More... - CB Index:61
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