Calicheamicin

• Product Name:Calicheamicin
• Synonyms: calicheamicin gamma(1)I Benzenecarbothioic acid, 4-((6-deoxy-3-o-methyl-alpha-L-mannopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methyl-, 4''-ester with methyl (8-((4,6-dideoxy-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentapyranosyl)-4-(((2,6-dideoxy-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)carbamate, (1R-(1R*,4Z,8S*,13E))- Calichemicin gamma1 Carbamic acid, ((1R,4Z,8S,13E)-8-((4,6-dideoxy-4-(((2,6-dideoxy-4-S-(4-((6-deoxy-3-o-methyl-alpha-L-mannopyranopyranosyl)oxy)-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-beta-D-ribo-hexopyranosyl)oxy)amino)-2-o-(2,4-dideoxy-4-(ethylamino)-3-o-methyl-alpha-L-threo-pentopyranosyl)-beta-D-glucopyranosyl)oxy)-1-hydroxy-13-(2-(methyltrithio)ethylidene)-11-oxobicyclo(7.3.1)trideca-4,9-diene-2,6-diyn-10-yl)-, methyl ester Calicheamicin γ1 LL-E 33288 gamma1-I calicheamicin gamma Calicheamicin γ1 purity>95
• CAS:108212-75-5
• MF:C55H74IN3O21S4
• MW:1368.34
• EINECS:
• Mol File:108212-75-5.mol
• 

Calicheamicin, also known as Calicheamicin gamma(1,I) or Calichemicin gamma1, is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule.

• Calicheamicin gamma1
• 
• US $8.00-1.00/kg
• CAS:108212-75-5
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: g-kg-tons, free sample is available
• 2024-04-05

• Company Name:SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD
• Tel: 13917490980
• Products Intro:Product Name:Calicheamicin
  CAS:108212-75-5
  Purity:95%;98%HPLC Package:10MG;1G;100G;1KG
• CB Index:58
• Related Information:Catalog(367)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Calicheamicin/Calicheamicin γ1
  CAS:108212-75-5
  Purity:>98% Package:100mg;500mg;1g
• CB Index:61
• Related Information:Catalog(6005)

• Company Name:Nanjing Sunlida Biological Technology Co., Ltd.
• Tel:025-57798810
• Products Intro:CAS:108212-75-5
  Purity:98% Package:1g;5g;25g;100g
• CB Index:55
• Related Information:Catalog(3239)

• Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
• Tel:18149758185 18149758185
• Products Intro:Product Name:Calicheamicin
  CAS:108212-75-5
  Purity:98% Package:1g;10g;100g
• CB Index:58
• Related Information:Catalog(3466)