7α,25-dihydroxy Cholesterol
64907-22-8 Basic informationMore
- Product Name:7α,25-dihydroxy Cholesterol
- Synonyms: 7-alpha,25-Dihydroxycholesterol 3β,7α,25-Trihydroxycholest-5-ene 5-Cholesten-3β,7α,25-triol 25-dihydroxycholesterol 7Α,25-DIHYDROXYCHOLESTEROL;7Α;25-DIHYDROXYCHOLESTEROL (3β,7α)-Cholest-5-ene-3,7,25-triol 7α,25-OHC 7α,25-dihydroxy Cholesterol
- CAS:64907-22-8
- MF:C27H46O3
- MW:418.65
- EINECS:
- Mol File:64907-22-8.mol
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USE
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.[Cayman Chemical]
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:3β,7α,25-Trihydroxycholest-5-ene
CAS:64907-22-8
Package:10Mg,2.5Mg,25Mg,5Mg More... - CB Index:76
- Related Information:Catalog(94657)
- Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
- Tel:020-39119399 18927568969
- Products Intro:Product Name:7α,25-Dihydroxycholesterol
CAS:64907-22-8
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G - CB Index:55
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- Company Name:ChemStrong Scientific Co.,Ltd
- Tel:0755-0755-66853366 13670046396
- Products Intro:Product Name:Cholesterol Impurity 33
CAS:64907-22-8
Purity:95% HPLC Package:10mg;25mg;50mg;100mg - CB Index:56
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- Company Name:Sigma-Aldrich
- Tel:021-61415566 800-8193336
- Products Intro:Product Name:7α,25-Dihydroxycholesterol
CAS:64907-22-8
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:SML0541 More... - CB Index:80
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- Company Name:Codow Chemical Co.,Ltd.
- Tel: 18620099427
- Products Intro:Product Name:7α,25-dihydroxycholesterol
CAS:64907-22-8
Purity:>99% Package:1MG;2.5MG;5MG;10MG More... - CB Index:55
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- Company Name:Chengdu Dianchun Technology Co., Ltd
- Tel:400-1166-196 18502815961
- Products Intro:Product Name:7α,25-dihydroxycholesterol
CAS:64907-22-8
Purity:99% HPLC Package:10g;50g;100g;500g;1kg;5kg;25kg More... - CB Index:60
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- Company Name:Amadis Chemical Company Limited
- Tel:571-89925085
- Products Intro:Product Name:7-alpha,25-Dihydroxycholesterol
CAS:64907-22-8
Purity:0.97 Package:mgs,gs,kgs Remarks:A929405 - CB Index:58
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- Company Name:Shanghai Jizhi Biochemical Technology Co. Ltd.
- Tel:4009004166/18616739031 18616739031
- Products Intro:Product Name:7α,25-dihydroxycholesterol
CAS:64907-22-8
Purity:98% Package:1mg;5mg Remarks:D13770 More... - CB Index:58
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