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Nelarabine is a prodrug for deoxyguanosine analogue 9-&beta;-arabinosyl guanine (ara-G). Ara-G has poor water solubility and can become Nelarabine with methoxy group in vivo. It was mono-phosphorylated into 5'-triphosphate ara-G, when catalyzed by adenosine deaminase and deoxycytidine kinase. Ara cells-GTP is accumulated in leukemia. PNP deficiency leads to the selective accumulation of dGTP in T cells, whereas dGTP rapidly degrades in B cells without accumulation in B cells. Intracellular accumulation of dGTP can inhibit DNA synthesis. Arabinosyl guanine can selectively kill cells with T cell leukemia, leading to cell death. Other mechanisms may be cytotoxicity and systemic toxicity of Nelarabine.<br /> Recurrent pharmacokinetic study of leukemia or lymphoma in patients found that Nelarabine and ara-G can eliminated in plasma quickly. the two half-life were 30 minutes and 3 hour when giving 1500mg/m2 dose of Nelarabine. The study also found that ara-G usually reached the peak concentration at the end of Nelarabine administration, and its peak concentration value is usually greater than the peak concentration of Nelarabine, indicating that Nelarabine in the body can be quickly and completely transformed into ara-G. Nelarabine and ara-G were partially abolished by the kidneys, and the mean renal excretion rates of Nelarabine and ara-G measured 24 hours after administration of Nelarabine in 28 adult patients were 6.6 &plusmn; 4.7% and 27 &plusmn; 15% .
Lastest Price from Nelarabine manufacturers
  • Nelarabine
  • US $1.00 /g
  • CAS:121032-29-9
  • Min. Order: 1g
  • Purity: 99.0%
  • Supply Ability: 5kg/month
  • 2021-07-26
  • nelarabine
  • US $15.00-10.00/KG
  • CAS:121032-29-9
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • 2021-07-13

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