Matrix metalloproteinase-9 (MMP-9), via activation by TNF-α, plays a key role in tumor invasion and metastasis. NF-κB activation inhibitor III is a compound that inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 μM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells. It has been used to disrupt NF-κB signaling in order to study the role of syndecans in mediating extracellular matrix integrity.
