Pristanic acid is a natural terpenoid acid present at micromolar concentrations in the plasma of healthy individuals. It is obtained from dietary sources or by the α-oxidation of phytanic acid , which occurs predominantly in peroxisomes. Pristanic acid is an agonist of PPARα (EC50 = 40 μM). It is also a substrate of the mammalian peroxisomal ATP-binding cassette (ABC) transporter ABCD3, which facilitates its delivery into peroxisomes for β-oxidation.
