Azido-PEG3-SS-PEG3-azide is a PEG linker containing two terminal azide moieties and a cleavable disulfide bond. The azide groups can undergo copper-catalyzed Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The disulfide bond can be cleaved via reduction reactions using a Dithiothreitol (DTT) reagent. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
