Dihomo-γ-Linolenic Acid-d6 (DGLA-d6) contains six deuterium atoms at the 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of DGLA by GC- or LC-mass spectrometry. Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, (PGs), including PGE1. In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.
