FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2?In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3?Blocks LSF-stimulated activation of DNA methyltransferase 1.4?Cell permeable.
