4,5-Dimethylthiophene-2-carboxaldehyde is a derivatized thiophene compound potentially useful as a building block for synthesis. The thiophene moiety is of particular interest to material design, and 4,5-Dimethylthiophene-2-carboxaldehyde presents the thiophene group with useful functionality for incorporation into materials, with the aldehyde group presenting a handle for different elaborating transformations.