IP3K Inhibitor is a cell-permeable 2,6-disubstituted purine compound that acts as a selective, ATP-competitive inhibitor of IP 3-K (IC50 = 10.2 M), the kinase that catalyzes the conversion of IP3 to IP4. Induces elevated cellular IP3 level and Ca2+-release in a dose-dependent manner (5 to 20 M in HL60 cells). IP3K Inhibitor exhibits negligible inhibitory effect on Cdk1 (IC50 >100 M) and two other IP3 metabolizing enzymes, PLC and IP3 5-ppase, even at concentrations as high as 200 M. IP3K Inhibitor is a useful alternative to the non-cell-permeable IP3 or IP3 analogs for studies involving intact cells.
