BMS 193885 is a potent, competitive NPY1-R antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, NPY2-R, NPY4-R and NPY5-R receptors respectively. Reduces food intake and body weight via central NPY1-R inhibition and is a brain penetrant.
