Methyltetrazine-PEG5-alkyne is a click chemistry bifunctional molecule containing an alkyne group and a hydrophilic PEG spacer which increases water-solubility. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule The alkynes can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.
