WZ4002 suppliers

WZ4002

CAS:: 1213269-23-8

MF:: C25H27ClN6O3

MW:: 494.97

Use：: WZ4002 also inhibit other EGFR genotypes. For instance, the IC50 is 2nM and 6nM respectively when it acts on E746_A750 and E746_A750/T790M. Besides, the IC50 is 32nM when it acts on wild-type EGFR. It could inhibit the phosphorylation of EGFR, AKT and ERK1/2 when it acts on non-small cell lung cancer (NSCLC). WZ4002 also could inhibit the phosphorylation of EGFR when it acts on NIH-3T3 cells expressing different EGFRT790M mutant alleles. The dissociation constant of kinase was 95% higher when in the test when WZ4002 involved than that in the test DMSO involved instead. Because in aniline substitution in the C2 WZ4002 could obtain a methoxy group when it acts on EGFR, thus its more effective when it acts on EGFR than WZ3146. Compared with the quinazoline inhibitors, the efficiency of WZ4002 is 100 times lower than when it acts on wild-type EGFR. The inhibitory effect of WZ4002 on EGFR kinase activity of recombinant L858R/T790M protein is much higher than restrainable wild-type EGFRs. However HKI-272 and Gefitinib are happened to have opposite inhibitory effect compared with WZ4002. In addition, phosphorylation of EGFR in H1975 and HCC827 cells of anti-Src TKI could be completely inhibited by third-generation EGFR TKI and WZ4002.

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You can find WZ4002 suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

ATK CHEMICAL COMPANY LIMITED

WZ4002
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

career henan chemical co

WZ4002
Remarks: Purity: 98% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Reagent

￥1.00/1KG

BOC Sciences

WZ-4002
Remarks: Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for WZ-4002.
UNITED STATES Trader

Chengdu Feibo Pharm Technology Co., Ltd

N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide HBr
Remarks: Purity: 95%+ | Package: 5g;50g;100g;250g;500g;1kg;5kg
TEL: 028-84641798
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

wz 4002
Remarks: Purity: 0.99 | Package: 1kg
CHINA Trader

career henan chemical co

WZ4002
Remarks: Purity: 97%-99.9% | Package: 1KG;1USD
TEL: 0371-86658258
CHINA Trader

￥1.00/1KG

TargetMol Chemicals Inc.

WZ4002
Remarks: Purity: 98.12% | Package: 5mg;44USD|10mg;67USD|25mg;119USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

Dideu Industries Group Limited

WZ4002
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: +86-29-89586680
CHINA Trader

AFINE CHEMICALS LIMITED

N-{3-[(5-CHLORO-2-{[2-METHOXY-4-(4-METHYL-1-PIPERAZINYL)PHENYL]AMINO}-4-PYRIMIDINYL)OXY]PHENYL}ACRYLAMIDE
Remarks: Purity: 99% | Package: USP EP CP
TEL: 0571-85134551
CHINA Trader

Dayang Chem (Hangzhou) Co.,Ltd.

WZ4002
Remarks: Purity: 0.95&0.99 | Package: 0.1KG;1KG;1000KG | CustNote: Factory Supply
TEL: 571-88938639
CHINA Trader