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ChemicalBook >> CAS DataBase List >>Valsartan

Valsartan suppliers

Valsartan

CAS:: 137862-53-4

MF:: C24H29N5O3

MW:: 435.52

SecurityInformation

Symbol(GHS) ：: GHS07,GHS08

Signal word ：: Warning

Hazard statements ：: H336-H361d

Precautionary statements ：: P201-P308+P313

Hazard Codes ：: Xi

Risk Statements ：: 36/37/38

Safety Statements ：: 26-37/39

WGK Germany ：: 3

RTECS ：: YV9455000

HS Code ：: 29339900

Use：: Valsartan selectively affects the AT1 receptor subtype and prevents AT1 from binding with AT1 receptors (its selective AT1 receptor antagonizing effect is about 20000 times greater than its effects on AT2 receptors), thus inhibiting vasoconstriction and aldosterone release, producing an antihypertensive effect, but it cannot inhibit the release of aldosterone caused by potassium ions (K+). Valsartan does not affect angiotensin-converting enzymes (ACE) or renin and its receptors, and it does not inhibit ion channels related to blood pressure regulation and sodium balance. Valsartan does not inhibit ACE and does not affect bodily bradykinin levels, thus causing less coughing side effects than ACE inhibitors. Valsartan does not affect heart rate when lowering blood pressure. Sudden ceasing in Valsartan use will not cause rebound hypertension or other side effects. Valsartan does not affect hypertension patients overall cholesterol, triglyceride, blood glucose, or uric acid levels.

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