Valrubicin suppliers

Valrubicin

CAS:: 56124-62-0

MF:: C34H36F3NO13

MW:: 723.64

Use：: Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription. In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

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You can find Valrubicin suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

R&D Scientific Inc.

Valrubicin
Remarks: Purity: 99 | Package: 5KG;1KG
TEL: +1-2266000236
CANADA Trader

￥1990.00/1g

career henan chemical co

Valrubicin
Remarks: Purity: 99% | Package: 3KG;3USD
TEL: 0371-86658258
CHINA Reagent

￥3.00/3KG

Xiamen AmoyChem Co., Ltd

Valrubicin
TEL: 592-+86-592-6051114
CHINA Service provider

BOC Sciences

Valrubicin
Remarks: Purity: >98% | Package: 5mg | CustNote: BOC Sciences also provides custom synthesis services for Valrubicin.
UNITED STATES Trader