Topotecan hydrochloride suppliers

Topotecan hydrochloride

CAS:: 119413-54-6

MF:: C23H24ClN3O5

MW:: 457.91

Use：: Topotecan hydrochloride is a water-soluble derivative of camptothecin, which is the form of hydrochloride of topotecan. It is successfully developed by the SmithKline Beecham US company, and approved by the FDA in the United States in 1996. Its trade name is Hycamtin. It is applied in the treatment of ovarian cancer (OVC) as the second-line therapy. In 1999 the US Food and Drug Administration (FDA) has approved topotecan hydrochloride as small cell lung cancer (SCLC) therapeutic drug. It has been available in the UK, Germany, France and other dozens of countries and regions. The Ⅲ clinical trials are ongoing for this medicine which is used to treat non-small cell lung cancer, cervical cancer, myelodysplastic syndrome. Topotecan hydrochloride can enter the blood brain barrier. It has the same effect of oral and intravenous injection. The drug has low toxicity predictable bone marrow suppression, and other minor non-hematologic toxicity. Currently there are manufacturers, for clinical treatment of small cell lung cancer, ovarian cancer and other tumors. Topotecan hydrochloride inhibits the activity of topoisomerase I, which is required for DNA replication. After intravenous injection, the product is hydrolyzed in the blood, and excreted by urinary. This product has a rapid serum clearance rate, which is 62L/h. It is widely distributed in vivo, and Its half-lifetime is about 2~3h. Preclinical trials have shown that the product has anti-tumor activity on all kinds of types of tumor. In I clinical trial, to patients with ovarian cancer that is cisplatin tolerance, this product also has significant anti-tumor effect.

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You can find Topotecan hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Hebei Mojin Biotechnology Co., Ltd

Topotecan hydrochloride
Remarks: Purity: 99% | Package: 25KG
TEL: 13288715578
CHINA Service provider

￥0.00/25KG

Hangzhou ICH Biofarm Co., Ltd

Topotecan hydrochloride
Remarks: Purity: 99% | Package: 1kg;|25kg
CHINA Trader

￥0.00/1kg

￥0.00/25kg

Shaanxi Haibo Biotechnology Co., Ltd

Topotecan hydrochloride
Remarks: Purity: 99%|Package: 25kg;0.00;USD
CHINA Trader

￥0.00/25kg

Shanghai Time Chemicals CO., Ltd.

Topotecan hydrochloride
TEL: 021-+86-021-57951555
CHINA Trader

Hangzhou FandaChem Co.,Ltd.

Topotecan hydrochloride
TEL: 008657128800458
CHINA Trader

ATK CHEMICAL COMPANY LIMITED

Topotecan hydrochloride
Remarks: Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
TEL: 21-51877795
CHINA Reagent

career henan chemical co

Topotecan hydrochloride
Remarks: Purity: 99% | Package: 1kg;2USD
TEL: 0371-86658258
CHINA Reagent

￥2.00/1kg

Chengdu Biopurify Phytochemicals Ltd.

Topotecan Hydrochloride
Remarks: Purity: 0.98 | Package: 10mg;20mg;50mg;100mg;500mg | CustNote: Can Be Customized in Bulk
TEL: +86-28-82633860
CHINA Reagent

Hebei Guanlang Biotechnology Co., Ltd.

Topotecan hydrochloride
Remarks: Purity: 99% | Package: 1KG;10USD
CHINA Trader

￥10.00/1KG

BOC Sciences

Topotecan Hydrochloride
Remarks: Purity: >98% | Package: 1g | CustNote: BOC Sciences also provides custom synthesis services for Topotecan hydrochloride.
UNITED STATES Trader